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Issue 20, 2011
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Insulin-binding aptamer-conjugated graphene oxide for insulin detection

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Abstract

This paper describes a simple and sensitive aptamer/graphene oxide (GO) based assay for insulin detection. GO can protect DNA from nuclease cleavage, but aptamers can be detached from the GO surface by specific target binding. This exposes the aptamers to enzymatic cleavage and releases the target for a new cycle. Cycling of targets leads to significant signal amplification and low LOD.

Graphical abstract: Insulin-binding aptamer-conjugated graphene oxide for insulin detection

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Article information


Submitted
17 May 2011
Accepted
27 Jul 2011
First published
26 Aug 2011

Analyst, 2011,136, 4138-4140
Article type
Communication

Insulin-binding aptamer-conjugated graphene oxide for insulin detection

Y. Pu, Z. Zhu, D. Han, H. Liu, J. Liu, J. Liao, K. Zhang and W. Tan, Analyst, 2011, 136, 4138
DOI: 10.1039/C1AN15407A

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