Issue 15, 2011
From the journal:

Analyst

Direct analysis of camptothecin from Nothapodytes nimmoniana by desorption electrospray ionizationmass spectrometry (DESI-MS)

Amitava Srimany,a   Demian R. Ifa,ab   Hemanta R. Naik,a   Vasudeva Bhat,a   R. Graham Cooksb  and  T. Pradeep*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Madras, Chennai, India
E-mail: pradeep@iitm.ac.in
Fax: +91 44 2257-0545
Tel: +91 44 2257 4208

b Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, USA
E-mail: cooks@purdue.edu
Fax: +1 765 494-9421
Tel: +1 765 494-5263

Abstract

Desorption electrospray ionization was employed for fast and direct ambient detection of the anti-tumor drug, camptothecin, and its derivative, 9-methoxycamptothecin in Nothapodytes nimmoniana. Different parts of the plant such as leaves, stems and bark were examined. The ion intensities suggest that the concentration in bark is higher than that in the leaves and stems. The method does not require any sample preparation or preseparation. The identity of the alkaloids was further confirmed by tandem mass spectrometry.

Graphical abstract: Direct analysis of camptothecin from Nothapodytes nimmoniana by desorption electrospray ionization mass spectrometry (DESI-MS)

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Article information

DOI
https://doi.org/10.1039/C1AN15339K
Article type
Communication
Submitted
21 Apr 2011
Accepted
02 Jun 2011
First published
21 Jun 2011

Analyst, 2011,136, 3066-3068

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Direct analysis of camptothecin from Nothapodytes nimmoniana by desorption electrospray ionization mass spectrometry (DESI-MS)

A. Srimany, D. R. Ifa, H. R. Naik, V. Bhat, R. G. Cooks and T. Pradeep, Analyst, 2011, 136, 3066 DOI: 10.1039/C1AN15339K

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