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Issue 8, 2011
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Vapor–liquid–solid grown silica nanowire based electrochemical glucose biosensor

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Abstract

Vapor–liquid–solid (VLS) grown silica nanowires (SiO2NWs) have been deposited electrophoretically on a gold electrode and utilized for covalent immobilization of glucose oxidase (GOx). Covalent binding has been achieved via3-aminopropyltriethoxysilane (APTES) modification and N-ethyl-N′-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide chemistry. Scanning electron microscopy, transmission electron microscopy and cyclic voltammetry techniques have been used to characterize SiO2NW and GOx/APTES/SiO2NW/Au bioelectrode. Electrochemical studies reveal that SiO2NW increases the effective electro-active surface area thus resulting in higher loading of enzyme. Response characteristics show linearity in the range of interest 25–300 mg dl−1, with a detection limit of 11 mg dl−1, sensitivity: 0.463 µA (mg dl−1)−1 and regression coefficient of 0.992.

Graphical abstract: Vapor–liquid–solid grown silica nanowire based electrochemical glucose biosensor

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Publication details

The article was received on 06 Dec 2010, accepted on 08 Feb 2011 and first published on 03 Mar 2011


Article type: Paper
DOI: 10.1039/C0AN00977F
Citation: Analyst, 2011,136, 1686-1689

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    Vapor–liquid–solid grown silica nanowire based electrochemical glucose biosensor

    E. Murphy-Pérez, S. K. Arya and S. Bhansali, Analyst, 2011, 136, 1686
    DOI: 10.1039/C0AN00977F

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