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Issue 3, 2011
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Gangliosides' analysis by MALDI-ion mobility MS

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The combination of ion mobility with matrix-assisted laser desorption/ionization allows for the rapid separation and analysis of biomolecules in complex mixtures (such as tissue sections and cellular extracts), as isobaric lipid, peptide, and oligonucleotide molecular ions are pre-separated in the mobility cell before mass analysis. In this study, MALDI-IM MS is used to analyze gangliosides, a class of complex glycosphingolipids that has different degrees of sialylation. Both GD1a and GD1b, structural isomers, were studied to see the effects on gas-phase structure depending upon the localization of the sialic acids. A total ganglioside extract from mouse brain was also analyzed to measure the effectiveness of ion mobility to separate out the different ganglioside species in a complex mixture.

Graphical abstract: Gangliosides' analysis by MALDI-ion mobility MS

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Article information

18 Sep 2010
08 Nov 2010
First published
29 Nov 2010

Analyst, 2011,136, 463-466
Article type

Gangliosides' analysis by MALDI-ion mobility MS

S. N. Jackson, B. Colsch, T. Egan, E. K. Lewis, J. A. Schultz and A. S. Woods, Analyst, 2011, 136, 463
DOI: 10.1039/C0AN00732C

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