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Issue 8, 2011
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Real-time reaction monitoring using ion mobility-mass spectrometry

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Abstract

The potential of ion mobility (IM) spectrometry in combination with mass spectrometry (MS) for real-time reaction monitoring is reported. The combined IM-MS approach using electrospray ionization affords gas-phase analyte characterization based on both mass-to-charge (m/z) ratio and gas-phase ion mobility (drift time). The use of IM-MS analysis is demonstrated for the monitoring of the reaction products formed when 7-fluoro-6-hydroxy-2-methylindole is deprotonated by aqueous sodium hydroxide. Real-time reaction monitoring was carried out over a period of several hours, with the reaction mixture sampled and analysed at intervals of several minutes. Product ion relative intensity is enhanced selectively in the ion mobility-selected mass spectrum, compared to mass spectrometry alone. The combined IM-MS approach has potential as a rapid and selective technique to aid pharmaceutical process control and for the elucidation of reaction mechanism.

Graphical abstract: Real-time reaction monitoring using ion mobility-mass spectrometry

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Publication details

The article was received on 09 Sep 2010, accepted on 03 Feb 2011 and first published on 25 Feb 2011


Article type: Paper
DOI: 10.1039/C0AN00700E
Analyst, 2011,136, 1728-1732

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    Real-time reaction monitoring using ion mobility-mass spectrometry

    E. L. Harry, A. W. T. Bristow, I. D. Wilson and C. S. Creaser, Analyst, 2011, 136, 1728
    DOI: 10.1039/C0AN00700E

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