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Issue 11, 2008
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New tools for rapid clinical and bioagent diagnostics: microwaves and plasmonic nanostructures

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Abstract

In this timely review, we summarize recent work on ultra-fast and sensitive bioassays based on microwave heating, and provide our current interpretation of the role of the combined use of microwave energy and plasmonic nanostructures for applications in rapid clinical and bioagent diagnostics. The incorporation of microwave heating into plasmonic nanostructure-based bioassays brings new advancements to diagnostic tests. A temperature gradient, created by the selective heating of water in the presence of plasmonic nanostructures, results in an increased mass transfer of target biomolecules towards the biorecognition partners placed on the plasmonic nanostructures, enabling diagnostic tests to be completed in less than a minute, and in some cases only a few seconds, by further microwave heating. The diagnostic tests can also be run in complex biological samples, such as human serum and whole blood.

Graphical abstract: New tools for rapid clinical and bioagent diagnostics: microwaves and plasmonic nanostructures

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Publication details

The article was first published on 18 Sep 2008


Article type: Highlight
DOI: 10.1039/B808292H
Analyst, 2008,133, 1469-1480

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    New tools for rapid clinical and bioagent diagnostics: microwaves and plasmonic nanostructures

    K. Aslan and C. D. Geddes, Analyst, 2008, 133, 1469
    DOI: 10.1039/B808292H

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