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Issue 10, 2008
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A near-infrared fluorescent probe for lipid hydroperoxides in living cells

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Abstract

An NIR (near-infrared) fluorescent probe TCP (tricarbocyanine diphenylphosphine) including a non-conjugated ‘pre-tricarbocyanine’ was designed and synthesized for visualizing lipid hydroperoxides (ROOH) in living cells. The excitation and emission spectra of tricarbocyanine in the NIR region can effectively avoid background fluorescence interference in biological systems. The probe exhibited a rapid fluorescence response to ROOH and high selectivity for ROOH over other ROS (reactive oxygen species) and some biological compounds, and the limit of detection was 38 pM. In addition, the probe was stable, and less cytotoxic, which indicated that it has potential application in detecting lipid hydroperoxides in living biological systems.

Graphical abstract: A near-infrared fluorescent probe for lipid hydroperoxides in living cells

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Article information


Submitted
19 Feb 2008
Accepted
21 Apr 2008
First published
15 May 2008

Analyst, 2008,133, 1409-1415
Article type
Paper

A near-infrared fluorescent probe for lipid hydroperoxides in living cells

P. Li, B. Tang, Y. Xing, P. Li, G. Yang and L. Zhang, Analyst, 2008, 133, 1409
DOI: 10.1039/B802836B

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