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Issue 3, 2008
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Opto-fluidic micro-ring resonator for sensitive label-free viral detection

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Abstract

We have demonstrated sensitive label-free virus detection using the opto-fluidic ring resonator (OFRR) sensor. The OFRR is a novel sensing platform that integrates the microfluidics and photonic sensing technology with a low detection limit and small volume. In our experiment, filamentous bacteriophage M13 was used as a safe model system. Virus samples were flowed through the OFRR whose surface was coated with M13-specific antibodies. We studied the sensor performance by monitoring in real-time the virus and antibody interaction. It is shown that OFRR can detect M13 with high specificity and sensitivity. The detection limit is approximately 2.3 × 103 pfu mL−1 and the detection dynamic range spanned seven orders of magnitude. Theoretical analysis was also carried out to confirm the experimental results. Our study will lead to development of novel OFRR-based, sensitive, rapid, and low-cost micro total analysis devices for virus detection.

Graphical abstract: Opto-fluidic micro-ring resonator for sensitive label-free viral detection

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Article information


Submitted
31 Oct 2007
Accepted
08 Dec 2007
First published
08 Jan 2008

Analyst, 2008,133, 356-360
Article type
Paper

Opto-fluidic micro-ring resonator for sensitive label-free viral detection

H. Zhu, I. M. White, J. D. Suter, M. Zourob and X. Fan, Analyst, 2008, 133, 356
DOI: 10.1039/B716834A

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