Establishing the synthetic origin of amphetamines by 2H NMR spectroscopy

Silvia Armellin; Elisabetta Brenna; Giovanni Fronza; Claudio Fuganti; Matteo Pinciroli; Stefano Serra

doi:10.1039/B308749B

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Establishing the synthetic origin of amphetamines by ²H NMRspectroscopy

Silvia Armellin,^a Elisabetta Brenna,*^a Giovanni Fronza,*^a Claudio Fuganti,^a Matteo Pinciroli^a and Stefano Serra^a

Author affiliations

* Corresponding authors

^a Dipartimento di Chimica, Materiali, Ingegneria Chimica, Politecnico di Milano, ed Istituto CNR per la Chimica del Riconoscimento Molecolare, Via Mancinelli 7, I-20131 Milano, Italy
E-mail: elisabetta.brenna@polimi.it, giovanni.fronza@polimi.it

Abstract

Nine samples of N-acetyl-3,4-methylenedioxyamphetamine (N-acetyl-MDA), prepared according to the most common synthetic procedures, are submitted to ²H NMR spectroscopy. The relative deuterium content at the various sites of the molecule is shown to depend on its synthetic history. The technique provides a chemical fingerprint of N-acetyl-MDAs and it can be used to trace back the precursor materials and the synthetic pathways employed in the preparation of the samples.

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Article information

DOI: https://doi.org/10.1039/B308749B
Article type: Paper
Submitted: 25 Jul 2003
Accepted: 23 Dec 2003
First published: 16 Jan 2004

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Analyst, 2004,129, 130-133

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Establishing the synthetic origin of amphetamines by ²H NMR spectroscopy

S. Armellin, E. Brenna, G. Fronza, C. Fuganti, M. Pinciroli and S. Serra, Analyst, 2004, 129, 130 DOI: 10.1039/B308749B

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