Quartz crystal resonant sensor (QCRS) model for label-free, small molecules—receptor studies

Abstract

Studying the binding mechanisms of potential drug candidates to receptors of interest is of huge importance to the pharmaceutical industry and laboratory workers worldwide. Reliable arrangements for following interactions between low molecular weight samples and their potential receptors without the requirement for labelling are uncommon. Quartz crystal resonant sensors (QCRS) are becoming established as label-free tools for observing the interactions between species in liquid media. Here we describe a new model based upon QCRS technology and novel thiol surface chemistry, capable of detecting the interactions between low molecular weight sugars and their host receptors in real-time.