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Issue 9, 1997
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Adsorptive Stripping Voltammetry of Bleomycin

Abstract

In 0.05 M H 2 SO 4 solution, two reductive peaks, P 1 and P 2 , of bleomycin were obtained. The peak potentials E P1 and E P2 were -0.83 and -1.09 V (versus Ag/AgCl), respectively. The sensitivity of P 2 was much higher than that of P 1 . The peak current of P 2 was proportional to the concentration of bleomycin over the range 1.0 ×10 -9 –1.0 × 10 -7 M with a detection limit of 5.0 × 10 -10 M using adsorptive voltammetry at an accumulation time of 120 s (E i = -0.80 V). The behaviour of the reduction wave was studied and applied to the determination of bleomycin in mouse serum. The reduction process of P 1 was irreversible with adsorptive characteristics and the adsorption behaviour obeyed the Frumkin adsorptive isotherm.The adsorptive coefficient β was 8.9 × 10 5 , the interaction factor α was 0.94 and the Gibbs energy of adsorption ΔG° was -33.93 kJ mol -1 . P 2 was an irreversible adsorption peak with catalytic hydrogen properties.

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Article type: Paper
DOI: 10.1039/A700436B
Analyst, 1997,122, 991-994

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    Adsorptive Stripping Voltammetry of Bleomycin

    X. Tan, J. Hu and Q. Li, Analyst, 1997, 122, 991
    DOI: 10.1039/A700436B

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