Kinetic determination of 1-{[4′-(aminocarbonyl)-1′-pyridinio]-methoxymethyl}-2-(hydroxyiminomethyl)pyridinium dichloride (HI-6) alone and in binary mixtures with 1,1′-(oxydimethylene)bis(4-hydroxyiminomethylpyridinium) dichloride (toxogonin) and 1,1′-(propane-1,3-diyl)bis(4-hydroxyiminomethylpyridinium) dibromide (TMB-4)

Abstract

The oxime, 1-{[4′-(aminocarbonyl)-1′-pyridinio]methoxymethyl}-2-(hydroxyiminomethyl)pyridinium dichloride (HI-6), catalyses the reaction of gold(III) with potassium iodide in alkaline media. As HI-6 is used as an extremely effective agent against nerve gas poisoning, this effect has been utilised to develop a kinetic method for the determination of HI-6. By using a stopped-flow technique it was possible to determine HI-6 in concentrations from 3.3 × 10^–7 to 6.0 × 10^–6M, with a relative standard deviation of 3%. The method was checked by determining HI-6 in various different tablets. The proposed method can be applied to the analysis of mixtures of HI-6 with the bispyridinium oximes, 1,1′-(oxydimethylene)bis(4-hydroxyiminomethyl-pyridinium) dichloride (Toxogonin) and 1,1′-(propane-1,3-diyl)bis(4-hydroxyiminomethylpyridinium) dibromide (TMB-4).