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Issue 10, 1989
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Application of the least-squares method in the matrix form: simultaneous spectrophotometric determination of rifampicin and isoniazid in binary pharmaceutical formulations

Abstract

A least-squares method in the matrix form is described for the simultaneous determination of rifampicin and isoniazid in a mixture. The method allows the rapid analysis of binary pharmaceutical formulations with minimum error. The concentration of each component in the mixture has been determined spectro-photometrically by measuring the absorbance of the mixture at 5-nm intervals from 230 to 290 nm. To calculate the matrix of the proportionality constant a standard mixture was used for each component. All data analyses were performed on a personal computer.

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Article information


Analyst, 1989,114, 1311-1314
Article type
Paper

Application of the least-squares method in the matrix form: simultaneous spectrophotometric determination of rifampicin and isoniazid in binary pharmaceutical formulations

K. K. Mahalanabis, D. Basu and B. Roy, Analyst, 1989, 114, 1311
DOI: 10.1039/AN9891401311

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