Reductive amperometric determination of nitrofurantoin and acetazolamide at a sessile mercury drop electrode using flow injection analysis

Abstract

The application of a laboratory-built sessile mercury drop detector in drug analysis has been illustrated by the flow injection amperometric determination of nitrofurantoin and acetazolamide. Nitrofurantoin was determined in the range 1–50 µg ml^–1 at –0.70 V vs. SCE in a carrier stream consisting of pH 7.5 Britton-Robinson buffer containing sulphite to lower the background oxygen level; acetazolamide was determined in the range 10–70 µg ml^–1 at –0.85 V vs. SCE in 0.1 M hydrochloric acid. The procedures were applied with good accuracy and precision to the determination of the drugs in tablet formulations.