Spectrophotometric determination of acetaminophen, oxyphenobutazone and salicylamide by nitration and subsequent complexation reactions

Abstract

A simple and sensitive spectrophotometric method for the assay of three antipyretic drugs through their nitration and subsequent complexation with an nucleophilic reagent is proposed. The experimental conditions leading to optimum chromagen stability and intensity were studied. The results of the application of the method to the assay of the test compounds in unit doses were compared statistically with those obtained by official methods, and demonstrated good accuracy and precision.