Molecular interaction errors in phase-solubility analysis
Abstract
Results are presented for the assay by phase-solubility analysis of ibufenac (4-isobutylphenylacetic acid) and of saccharin in the presence of various impurities. The results for impurities obtained for ibufenac mixtures were almost twice those expected, while those for saccharin mixtures were normal. From a consideration of these results, the effect of compound formation by molecular interaction is discussed.