Ion exchange in non-aqueous media: the anion-exchange behaviour of phenols on De-Acidite FF resin in methanolic media

Abstract

The applications of ion-exchange resins to separations of organic compounds in non-aqueous media are briefly surveyed. The technique has been examined for its potential in separating phenols of high pK_a and of closely similar pK_a values. The latter can be resolved by a rigorous combination of the use of amine-acetic acid buffer solutions in methanol, and gradient elution. The mononitrophenols, cresols and xylenols have been examined and the weakly acidic xylenols are considered to represent the extreme practical limit of the method.