Issue 2, 1997

Direct Electrochemical Measurement of Nitric Oxide Production by Cytochrome P450-catalyzed Oxidation of N,N′-Substituted Hydroxyguanidines

Abstract

The production of nitric oxide by oxidative cleavage of N- hydroxyguanidines catalyzed by rat liver microsomes was measured directly, and for the first time by differential-pulse amperometry at a Nafion–porphyrin coated micro-sensor. The measured concentration of the nitric oxide produced (0.18–0.25 µM) was lower than the total concentration of the stored nitrites. The difference in the obtained data is discussed.

Article information

Article type
Paper

Anal. Commun., 1997,34, 69-71

Direct Electrochemical Measurement of Nitric Oxide Production by Cytochrome P450-catalyzed Oxidation of N,N′-Substituted Hydroxyguanidines

S. Trévin, S. André, J. Devynck, J. Luc Boucher and F. Bedioui, Anal. Commun., 1997, 34, 69 DOI: 10.1039/A608091J

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