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Issue 2, 1997
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Direct Electrochemical Measurement of Nitric Oxide Production byCytochrome P450-catalyzed Oxidation of N,N′-SubstitutedHydroxyguanidines


The production of nitric oxide by oxidative cleavage of N- hydroxyguanidines catalyzed by rat liver microsomes was measured directly, and for the first time by differential-pulse amperometry at a Nafion–porphyrin coated micro-sensor. The measured concentration of the nitric oxide produced (0.18–0.25 µM) was lower than the total concentration of the stored nitrites. The difference in the obtained data is discussed.

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Article type: Paper
DOI: 10.1039/A608091J
Anal. Commun., 1997,34, 69-71

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    Direct Electrochemical Measurement of Nitric Oxide Production by Cytochrome P450-catalyzed Oxidation of N,N′-Substituted Hydroxyguanidines

    S. Trévin, S. André, J. Devynck, J. Luc Boucher and F. Bedioui, Anal. Commun., 1997, 34, 69
    DOI: 10.1039/A608091J

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