Selective Functionalization of 1-substituted-3-arylquinoxalin-2(1H)-ones via C–H activation

Abstract

Over the past few decades, transition-metal-catalyzed selective functionalization of C–H bonds has fascinated the scientific community by offering striking advantages in comparison to traditional methods, such as high atom economy, a reduced number of reaction steps, and milder reaction conditions. Moreover, directing-group-assisted C–H activation enhances the significance of transition-metal catalysis further by enabling precise and site-selective functionalization. This mini-review outlines recent advancements in the imine-directed, transition-metal-catalyzed selective functionalization of N-alkyl-3-phenylquinoxalin-2(1H)-ones, highlighting C–C, C–O, C–X (X = Cl, Br, and I), C–S, and C–Se bond formation reactions and mechanistic aspects of these transformations.