Cobalt catalysis in organic synthesis: a powerful tool in the synthesis of natural products and pharmaceutically active compounds

Abstract

Cobalt-mediated catalysis has proven to be a potent and versatile method in the realm of present-day organic synthesis, facilitating the synthesis of biologically significant natural products and complex molecules. The field of natural product chemistry has always provided crucial advancements in the field of chemical science and pharmacology. Cobalt-mediated catalysis play a significant role towards the synthesis of biologically significant natural products, such as alkaloids, terpenoids, diterpenoids, polyketides, glycoside containing natural products, macrolides, as well as pharmaceutically active compounds such as nirmatrelvir, (S)-pazinaclone and MK-0371 etc. The present review focuses on the importance and applications of cobalt-mediated catalysis towards the synthesis of biologically significant natural products and pharmaceutical drugs, reported since 2018.