2-Pyridone-assisted palladium-catalyzed regioselective arylation of naphthamides

Abstract

The 2-pyridone scaffold receives attention in medicinal chemistry due to its bioisostere properties, which significantly contributing to lipophilicity, solubility, metabolic stability, and drug off-target effects. In the present article, we report the 2-pyridone-assisted regioselective arylation of naphthamides. Using diversified naphthamides and aryl iodides, a wide variety of 2-pyridone-containing molecular scaffolds were synthesized in good yields, which could be potentially useful in medicinal chemistry.