Total synthesis of natural products facilitated by prins reaction: a review

Abstract

Natural products have been identified as bioactive compounds, featuring anticancer, antibacterial, antiviral and anti-inflammatory properties. Synthesis of natural products is the field of high interest with an ongoing need for efficient synthetic methodologies leading to these intricate compounds. Prins reaction is one of the valuable strategies for the construction of sophisticated natural products and their derivatives. In this account, we have reviewed recent research accomplishments in synthesizing several natural products such as alkaloids, terpenoids, polyketides, steroids, spiroketals and polyphenolic compounds utilizing Prins protocol.