Tandem electrophilic thiocyanation/cyclization of α-alkynyl oximes for synthesis of 4-thiocyanatoisoxazoles

Abstract

A tandem electrophilic thiocyanation/cyclization of 1,3-diphenyl-2-propyn-1-one O-methyloxime has been achieved under mild conditions. This method provides efficient access to a series of thiocyanato-containing isoxazole derivatives in moderate to excellent yields, demonstrating broad substrate scope and good functional group tolerance.