Cell instructive hydrogels functionalized with polymerized DNA nanostructures

Hee Yeon Kim; Young Min Kim; Keonwook Nam; Kyungjik Yang; Joohyun Oh; Su-Min Han; Young Hoon Roh

doi:10.1039/D5NH00521C

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Cell instructive hydrogels functionalized with polymerized DNA nanostructures

Hee Yeon Kim,†^a Young Min Kim,†^a Keonwook Nam,^a Kyungjik Yang,^a Joohyun Oh,^a Su-Min Han^a and Young Hoon Roh

*^a

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* Corresponding authors

^a Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, South Korea
E-mail: yr36@yonsei.ac.kr

Abstract

Novel hyaluronic acid hydrogels functionalized with polymerized DNA nanostructures using rolling circle amplification were developed. These hydrogels exhibited enhanced cell attachment and proliferation through functional DNA-mediated interactions. The system maintained favorable physicochemical properties and enhanced interactions with biological interfaces, demonstrating potential for advanced 3D cell culture applications.

This article is part of the themed collections: DNA Nanotechnology and Nanoscale Horizons Covers

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DOI: https://doi.org/10.1039/D5NH00521C
Article type: Communication
Submitted: 22 Jul 2025
Accepted: 04 Nov 2025
First published: 02 Dec 2025

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Nanoscale Horiz., 2026,11, 469-477

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Cell instructive hydrogels functionalized with polymerized DNA nanostructures

H. Y. Kim, Y. M. Kim, K. Nam, K. Yang, J. Oh, S. Han and Y. H. Roh, Nanoscale Horiz., 2026, 11, 469 DOI: 10.1039/D5NH00521C

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Nanoscale Horizons

Cell instructive hydrogels functionalized with polymerized DNA nanostructures

Abstract

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Cell instructive hydrogels functionalized with polymerized DNA nanostructures

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