Effect of single xeno-nucleic acid replacement on the fluorescence of DNA-encapsulated silver nanoclusters

Hari Chandana Yadavalli; Riddhi Nagda; Jooyoun Kang; Minhaeng Cho; Chenguang Lou; Seong Wook Yang; Peter Waaben Thulstrup; Morten Jannik Bjerrum; Pratik Shah

doi:10.1039/D5NA00862J

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Effect of single xeno-nucleic acid replacement on the fluorescence of DNA-encapsulated silver nanoclusters

Hari Chandana Yadavalli,†^af Riddhi Nagda,†^ae Jooyoun Kang,^b Minhaeng Cho,

^bc Chenguang Lou,

^d Seong Wook Yang,*^a Peter Waaben Thulstrup,

*^e Morten Jannik Bjerrum

*^e and Pratik Shah

*^f

Author affiliations

* Corresponding authors

^a Department of Systems Biology, Institute of Life Science and Biotechnology, Yonsei University, Seoul, Korea
E-mail: yang@yonsei.ac.kr

^b Center for Molecular Spectroscopy and Dynamics, Institute for Basic Science, Seoul 02841, Korea

^c Department of Chemistry, Korea University, Seoul 02841, Republic of Korea

^d Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark

^e Department of Chemistry, University of Copenhagen, Copenhagen 2100, Denmark
E-mail: mobj@chem.ku.dk, pwt@chem.ku.dk

^f Department of Science and Environment, Roskilde University, Roskilde 4000, Denmark
E-mail: shah@ruc.dk

Abstract

The fluorescent properties of DNA/AgNCs are largely governed by the composition of AgNCs, the nucleobase sequence, and the secondary structure of the DNA template. Here, by systematic incorporation of xeno-nucleic acid modifications, we demonstrate the potential of altering the sugar chemistry of the template DNA backbone, as a novel factor in AgNC fluorescence modulation.

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Article information

DOI: https://doi.org/10.1039/D5NA00862J
Article type: Communication
Submitted: 08 Sep 2025
Accepted: 24 Dec 2025
First published: 05 Jan 2026
This article is Open Access

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Nanoscale Adv., 2026,8, 1191-1196

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Effect of single xeno-nucleic acid replacement on the fluorescence of DNA-encapsulated silver nanoclusters

H. C. Yadavalli, R. Nagda, J. Kang, M. Cho, C. Lou, S. W. Yang, P. W. Thulstrup, M. J. Bjerrum and P. Shah, Nanoscale Adv., 2026, 8, 1191 DOI: 10.1039/D5NA00862J

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Effect of single xeno-nucleic acid replacement on the fluorescence of DNA-encapsulated silver nanoclusters

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Effect of single xeno-nucleic acid replacement on the fluorescence of DNA-encapsulated silver nanoclusters

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