Amphiphilic poly(aminoester) dendrimers: click reaction–enabled synthesis, structure-governed self-assembly and degradation

Abstract

Poly(aminoester) (PAE) dendrimers are attractive materials for biomedical applications owing to their biodegradability and precise structure, effective synthesis and favourable safety profile. We report here a click chemistry–enabled divergent–convergent strategy for the efficient synthesis of amphiphilic PAE dendrimers. These dendrimers exhibit negligible cytotoxicity, generation-dependent degradation behaviour, and tunable self-assembly controlled by the hydrophobic chain length. This study offers an accessible synthesis of PAE dendrimers, advancing their use in future biomedical applications.