Liposome-based delivery of DNA aptamers to inhibit erythromycin methyltransferase-mediated antibiotic resistance
P. I.
Pradeepkumar 
a
and
Ruchi
Anand
*a
a
and
Ruchi
Anand
*a
Abstract
Resistance to macrolides, lincosamides, and the streptogramin B class of antibiotics is caused by the methylation activity of erythromycin methyltransferases. Here, we encapsulated DNA aptamers inhibiting Erm into specifically designed liposomes to enhance stability, uptake, and delivery properties. This delivery system restores erythromycin sensitivity in resistant Staphylococcus aureus, offering a promising therapeutic platform against MDR bacteria.
- This article is part of the themed collection: Advances in Computational Protein Design, Structural Biology, and Drug Discovery
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