Imaging of viscosity in ferroptosis-mediated acute alcoholic gastric injury and tumor models using an endoplasmic reticulum fluorescent probe

Abstract

We developed an endoplasmic reticulum (ER) fluorescent probe (ER-V) for viscosity detection. Importantly, using ER-V, we first revealed an increased ER viscosity in ferroptosis-mediated acute alcoholic gastric injury tissues, tumor mice, and even clinical patient tissue samples.