High-throughput chiral analysis using automated desorption electrospray ionization mass spectrometry

Jie Li; Nicolás M. Morato; Bo Hao; Ainslie Chen; Lucile Jouffroy; Ho Kim; Zhicai Shi; Karel Goossens; Iulia I. Strambeanu; R. Graham Cooks

doi:10.1039/D5CC06641G

High-throughput chiral analysis using automated desorption electrospray ionization mass spectrometry

Jie Li,

^ab Nicolás M. Morato,

^c Bo Hao,^a Ainslie Chen,^b Lucile Jouffroy,^d Ho Kim,^a Zhicai Shi,^a Karel Goossens,

^d Iulia I. Strambeanu

*^a and R. Graham Cooks

*^bc

Author affiliations

* Corresponding authors

^a Chemistry Capabilities, Analytical and Purification, Global Discovery Chemistry, Johnson & Johnson, Spring House, PA 19477, USA

^b Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
E-mail: cooks@purdue.edu

^c Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA

^d Chemical Process Research and Development, Therapeutics Development & Supply, Johnson & Johnson, 2340 Beerse, Belgium

Abstract

Rapid chiral analysis is important for high-throughput experimentation in drug development. Here, we implement the so-called “kinetic method” on an automated DESI-MS platform for the fast and separation-free enantiomeric analysis (0.2 min per sample) of a variety of chiral molecules directly from mixtures.

Chemical Communications

High-throughput chiral analysis using automated desorption electrospray ionization mass spectrometry

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High-throughput chiral analysis using automated desorption electrospray ionization mass spectrometry

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