Issue 13, 2026

NIR fluorescent probe for accurate diagnosis of acute kidney injury by monitoring leucine aminopeptidase

Abstract

Probe ECL could be activated by LAP with high sensitivity and excellent selectivity to emit NIR fluorescence. ECL-based fluorescence imaging of AKI achieved earlier diagnosis than serum marker determination and histological analysis of the kidneys. Furthermore, ECL was successfully used to monitor the progression of renal injury during breast cancer chemotherapy.

Graphical abstract: NIR fluorescent probe for accurate diagnosis of acute kidney injury by monitoring leucine aminopeptidase

Supplementary files

Article information

Article type
Communication
Submitted
18 Nov 2025
Accepted
23 Jan 2026
First published
26 Jan 2026

Chem. Commun., 2026,62, 4080-4084

NIR fluorescent probe for accurate diagnosis of acute kidney injury by monitoring leucine aminopeptidase

X. Xia, M. Huang, Z. Zhou, Y. Chen, P. Peng, E. Wang, F. Wang and J. Ren, Chem. Commun., 2026, 62, 4080 DOI: 10.1039/D5CC06544E

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