Benchtop NMR signal enhancement of metabolites in urine extract using SABRE
Simon
Fleischer, 
*a
Jing
Yang,
a
Kerti
Ausmees,
b
Indrek
Reile,
b
Neil
MacKinnon,
a
Jan Gerrit
Korvink
a
and
Sören
Lehmkuhl
*a
*a
Jing
Yang,
a
Kerti
Ausmees,
b
Indrek
Reile,
b
Neil
MacKinnon,
a
Jan Gerrit
Korvink
a
and
Sören
Lehmkuhl
*a
Abstract
Metabolites in a urine extract are signal-enhanced by SABRE hyperpolarization and detected using a benchtop NMR spectrometer. Quantification by standard addition is demonstrated for endogenic urinary nicotinamide (vitamin B3). Even higher sensitivity is achieved in an automated setup for multi-scan SABRE experiments. This hyperpolarization scheme is able to expedite biomarker detection and quantification, while maintaining low infrastructure requirements.
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