Cyclic peptide-based shear-thinning and self-healing hydrogels as injectable nanotherapeutics

Fátima Santillán; Yasmeen Shamiya; Aishik Chakraborty; Alap Ali Zahid; Lorena Veliz; François Lagugné-Labarthet; Leonard G. Luyt; Arghya Paul

doi:10.1039/D5BM01544H

Cyclic peptide-based shear-thinning and self-healing hydrogels as injectable nanotherapeutics

Fátima Santillán,

^a Yasmeen Shamiya,

^a Aishik Chakraborty,

^b Alap Ali Zahid,

^c Lorena Veliz,

^a François Lagugné-Labarthet,

^a Leonard G. Luyt

^ade and Arghya Paul

*^ac

Author affiliations

* Corresponding authors

^a Department of Chemistry, Western University, 1151 Richmond St, London, Ontario, Canada
E-mail: arghya.paul@uwo.ca

^b Chemical and Industrial Processes Engineering, Faculty of Engineering, Bahrain Polytechnic, Isa Town, The Kingdom of Bahrain

^c Department of Chemical and Biochemical Engineering, Western University, 1151 Richmond St, London, Ontario, Canada

^d Departments of Oncology and Medical Imaging, Western University, London, Ontario, Canada

^e Verspeeten Family Cancer Centre, London Health Sciences Centre, 800 Commisioners Rd, London, Ontario, Canada

Abstract

An injectable cyclic peptide-based hydrogel (cpGel) governed by supramolecular interactions between cyclic octapeptide nanofibers and LAPONITE® was developed. We demonstrated its excellent injectability, elasticity, and self-healing properties through rheological analyses. Further, we showed that cpGel is cytocompatible and that vancomycin-loaded cpGel can effectively inhibit the growth of MRSA and E. coli.

This article is part of the themed collections: Biomaterials Science Open Access Spotlight and Biomaterials Science Emerging Investigator Series

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Article information

DOI: https://doi.org/10.1039/D5BM01544H
Article type: Communication
Submitted: 19 Oct 2025
Accepted: 16 Feb 2026
First published: 20 Feb 2026
This article is Open Access

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Biomater. Sci., 2026,14, 1411-1417

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Cyclic peptide-based shear-thinning and self-healing hydrogels as injectable nanotherapeutics

F. Santillán, Y. Shamiya, A. Chakraborty, A. A. Zahid, L. Veliz, F. Lagugné-Labarthet, L. G. Luyt and A. Paul, Biomater. Sci., 2026, 14, 1411 DOI: 10.1039/D5BM01544H

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Biomaterials Science

Cyclic peptide-based shear-thinning and self-healing hydrogels as injectable nanotherapeutics

Abstract

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Cyclic peptide-based shear-thinning and self-healing hydrogels as injectable nanotherapeutics

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