Palladium-catalyzed amidocarbonylation of thioethers: access to α-amide-substituted thioether derivatives

Abstract

Thioethers play a crucial role as structural components in a wide range of natural products, pharmaceuticals, and industrial materials, influencing their chemical characteristics and biological functions. Herein, we report a palladium-catalyzed aminocarbonylation reaction of thioethers with amines as nucleophiles. This palladium-catalyzed carbonylation reaction features a wide substrate scope and functional group tolerance, enabling the efficient C(sp³)–H aminocarbonylation of thioethers to afford the corresponding amides in good yields.