Identification of a photoredox-active Pt(IV) complex that induces light-mediated cell death

Jevon W. Marsh; Lina Hacker; Sophie A. Twigger; Jake A. Vickery; Shitong Huang; Claudia Almuzara Romero; Aaron P. Langston; Ismael Diez-Perez; Rebecca A. Musgrave; Ester M. Hammond; Adam C. Sedgwick

doi:10.1039/D5SC02879E

Identification of a photoredox-active Pt(IV) complex that induces light-mediated cell death

Jevon W. Marsh,†^a Lina Hacker,†^b Sophie A. Twigger,

†^b Jake A. Vickery,

^c Shitong Huang,^a Claudia Almuzara Romero,^c Aaron P. Langston,^c Ismael Diez-Perez,

^c Rebecca A. Musgrave,

^c Ester M. Hammond

*^b and Adam C. Sedgwick

*^ac

Author affiliations

* Corresponding authors

^a Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK

^b Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK

^c Department of Chemistry, King's College London, 7 Trinity Street, London, UK
E-mail: adam.sedgwick@kcl.ac.uk

Abstract

We report the synthesis and characterisation of a series of fluorogenic Pt(IV) complexes – CarboBlue, OxaliBlue and CisBlue. These Pt(IV) complexes were identified as photoactive, oxidising biomolecules under light irradation to then undergo rapid intramolecular photoreduction to release the fluorescent reporter, Nap-OH and corresponding Pt(II) species. OxaliBlue and CisBlue displayed cytotoxicity regardless of light irradiation. In contrast, HCT116 cells treated with CarboBlue displayed a light-dependent increase in fluorescence emission along with selective light-induced toxicity.

Chemical Science

Identification of a photoredox-active Pt(IV) complex that induces light-mediated cell death

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Identification of a photoredox-active Pt(IV) complex that induces light-mediated cell death

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