Issue 59, 2025, Issue in Progress
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RSC Advances

7-Amino-2-(N,N-dimethylamino)quinazoline: a small, bright, easily synthesized scaffold for pH sensors

Mohammed Mahdaly,a   Takeshi Maki,a   Ryuji Osako,a   Yuki Fujimakia  and  Yumiko Suzuki ORCID logo *a  

* Corresponding authors

a Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554, Japan
E-mail: yumiko_suzuki@sophia.ac.jp

Abstract

This study reports a series of pH-responsive 2-(N,N-dimethylamino)quinazolines bearing amino substituents at position 7. These compounds exhibited tunable fluorescence (FL) enhancements under both acidic and basic conditions. Due to their small size, ease of synthesis, and strong fluorescence, these probes show promise for the development of pH sensors suitable for biological or environmental applications.

Graphical abstract: 7-Amino-2-(N,N-dimethylamino)quinazoline: a small, bright, easily synthesized scaffold for pH sensors

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Article information

DOI
https://doi.org/10.1039/D5RA07429K
Article type
Paper
Submitted
30 Sep 2025
Accepted
09 Dec 2025
First published
16 Dec 2025
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2025,15, 50565-50570

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7-Amino-2-(N,N-dimethylamino)quinazoline: a small, bright, easily synthesized scaffold for pH sensors

M. Mahdaly, T. Maki, R. Osako, Y. Fujimaki and Y. Suzuki, RSC Adv., 2025, 15, 50565 DOI: 10.1039/D5RA07429K

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