Fe3O4/cellulose/Zn-MOF: introduction of a new catalyst for the synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles and diphenyl-1,3-thiazoles under solvent-free conditions

Abstract

In this research, a novel, magnetically recoverable heterogeneous catalyst, Fe₃O₄/cellulose/Zn-MOF, was synthesized and thoroughly characterized using EDX, EDX mapping, FT-IR, SEM, TGA, XRD, and VSM to determine its physicochemical properties. Then, its catalytic activity was explored through one-pot, solvent-free, three-component reactions for the synthesis of diphenyl-1,3-thiazoles and tetrazolo[1,5-a]pyrimidine-6-carbonitriles. The system exhibited several outstanding properties, including excellent recyclability (over 5 successive rounds), low catalyst loading, remarkable product purity and yield, and a simplified work-up procedure, rendering it a promising candidate from a green chemistry perspective.