Extraction and determination of esteric compounds in wound disinfectants

Abstract

This study focuses on developing an analytical method to efficiently extract and concentrate several adipate and phthalate plasticizers that can migrate from plastic packaging into various wound disinfectants. The study employed an approach that combined dispersive micro solid phase extraction with dispersive liquid–liquid microextraction using ZIF-4 as an adsorbent. The adsorbent was thoroughly characterized to understand its properties. The microextraction step concentrated the target compounds for analysis using gas chromatography. After plasticizer adsorption onto ZIF-4, the analytes were desorbed using acetonitrile. The method demonstrated good performance by high extraction recoveries (61–95%) and enrichment factors (305–475), low detection (0.16–0.28 μg L⁻¹) and quantification (0.54–0.93 μg L⁻¹) limits, and good precision (relative standard deviation less than 7% for intra- and inter-day precisions).