Issue 3, 2025

Carbamoylation of azaarenes and olefins with formamides through dual photoredox/HAT catalysis

Abstract

A unique strategy for the photoinduced Minisci and Giese carbamoylation with readily available formamides is described. This approach avoids using less atom-efficient carbamoyl precursors (e.g., oxamic acids) and sacrificial oxidants, relying on dual photoredox/hydrogen atom transfer (HAT) catalysis. The synthetic value of the carboxamide functionality was illustrated with different straightforward transformations that gave access to diverse azaarene derivatives.

Graphical abstract: Carbamoylation of azaarenes and olefins with formamides through dual photoredox/HAT catalysis

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Article information

Article type
Research Article
Submitted
30 Oct 2024
Accepted
22 Nov 2024
First published
26 Nov 2024
This article is Open Access
Creative Commons BY-NC license

Org. Chem. Front., 2025,12, 772-778

Carbamoylation of azaarenes and olefins with formamides through dual photoredox/HAT catalysis

M. Martos, B. Quevedo-Flores, L. Laze, I. Bosque and J. C. Gonzalez-Gomez, Org. Chem. Front., 2025, 12, 772 DOI: 10.1039/D4QO02040E

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