Ruthenium(ii)-catalyzed regioselective C–H alkylation of pyridotriazoles with maleimides: access to triazolopyridine–succinimide scaffolds

Abstract

A regioselective Ru(II)-catalyzed C–H alkylation of pyridotriazoles with N-substituted maleimides has been developed to access triazolopyridine–succinimide frameworks. The method operates under mild conditions and exhibits a broad substrate scope with good to excellent product yields, excellent regioselectivity and functional group tolerance. Control and mechanistic experiments confirm a non-radical pathway involving a cyclometalated Ru(II) intermediate. The present procedure is also applicable to gram scale reactions.