Issue 3, 2025
From the journal:

Natural Product Reports

Total synthesis of isoflavonoids

Mamoalosi A. Selepe, ORCID logo *a   Siyanda T. Mthembub  and  Molahlehi S. Sonopoc  

* Corresponding authors

a Department of Chemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Lynnwood Road, Hatfield, Pretoria 0002, South Africa
E-mail: mamoalosi.selepe@up.ac.za

b Department of Physical and Earth Sciences, Faculty of Natural and Applied Sciences, Sol Plaatje University, P/Bag x 5008, Kimberley, South Africa

c Applied Radiation Department, South African Nuclear Energy Corporation Ltd, Pelindaba, Brits 0240, South Africa

Abstract

Covering: 2012 to 2024

Isoflavonoids are phenolic compounds with wide structural diversity and a plethora of biological activities. Owing to their structural variation and potential health-promoting and other benefits, they have been targeted for synthesis. Herein, we review the synthesis of natural isoflavonoids belonging to different classes that include isoflavones, isoflavanones, isoflavans, isoflavenes, pterocarpans, rotenoids, coumaronochromones, and coumestans. The synthetic methodologies employed and advancements in synthetic strategies are highlighted.

Graphical abstract: Total synthesis of isoflavonoids

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Article information

DOI
https://doi.org/10.1039/D4NP00060A
Article type
Review Article
Submitted
31 Oct 2024
First published
11 Feb 2025
This article is Open Access
Creative Commons BY-NC license

Nat. Prod. Rep., 2025,42, 540-591

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Total synthesis of isoflavonoids

M. A. Selepe, S. T. Mthembu and M. S. Sonopo, Nat. Prod. Rep., 2025, 42, 540 DOI: 10.1039/D4NP00060A

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