Synthesis of a pyrroloquinoline-containing polycyclic scaffold via decarboxylative [3+2] cycloaddition and aza-Wittig reactions

Abstract

A two-step reaction process involving decarboxylative [3+2] cycloaddition followed by the intramolecular aza-Wittig reaction is developed for making novel 5,5,6,6-fused polycyclic scaffold-containing pyrroloquinolines. The use of polymer-supported Ph₃P in the aza-Wittig reaction simplified the removal of Ph₃P(O) and reduced the loss of product during purification.