Tailored Mesoporous Silica Nanoparticles for Overcoming Gastrointestinal Barriers: A Perspective on Advanced Strategies for Oral Delivery

Abstract

Mesoporous silica nanoparticles (MSNs) offer new opportunities for the oral delivery of peptide drugs and biologics, owing to their biocompatibility and high drug-loading capacity. This perspective article explores strategies for the synthesis and functionalization of tailored MSNs, enabling precise control over particle size, morphology, and surface chemistry to overcome gastrointestinal barriers and enhance oral drug bioavailability.