Issue 11, 2025
From the journal:

New Journal of Chemistry

A large-Stokes shift styryl pyridinium derivative with a stable green-light emission for imaging mitochondria in live cells†

Chathura S. Abeywickrama, ORCID logo *a   Kavinda M. Arachchige,a   Kaveesha J. Wijesinghe, ORCID logo b   Robert V. Stahelin ORCID logo c  and  Yi Pang ORCID logo d  

* Corresponding authors

a Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA
E-mail: chathura.abeywickrama@uconn.edu

b Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka

c Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA

d Department of Chemistry, University of Akron, OH 44325, USA

Abstract

A green-light-emitting styryl pyridinium probe (EPN) was developed for live-cell imaging applications. EPN exhibited a large Stokes shift (Δλ ≈ 150 nm), due to an efficient ICT across the π–acceptor system. The probe exhibited exceptional biocompatibility and excellent specificity for cellular mitochondria. EPN exhibited great photostability to continuous irradiation and exhibited stable emission in cells up to 5 hours post-staining.

Graphical abstract: A large-Stokes shift styryl pyridinium derivative with a stable green-light emission for imaging mitochondria in live cells

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Article information

DOI
https://doi.org/10.1039/D4NJ05398B
Article type
Communication
Submitted
18 Dec 2024
Accepted
20 Feb 2025
First published
21 Feb 2025
This article is Open Access
Creative Commons BY-NC license

New J. Chem., 2025,49, 4303-4307

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A large-Stokes shift styryl pyridinium derivative with a stable green-light emission for imaging mitochondria in live cells

C. S. Abeywickrama, K. M. Arachchige, K. J. Wijesinghe, R. V. Stahelin and Y. Pang, New J. Chem., 2025, 49, 4303 DOI: 10.1039/D4NJ05398B

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