Absorption and anti-bacterial studies of an acetylene-functionalized Schiff base for detection of Sn(ii) and inhibition of E. coli

Abstract

In this study, a quick-sensing naphthalene Schiff base receptor ((1E,1′E)-N,N-(naphthalene-1,5-diyl)bis(1-(4-(prop-2-yn-1-yloxy)phenyl)methanimine)) denoted as 4 was synthesized in order to meet the urgent requirement for Sn(II) detection. 4 was well characterized using NMR spectroscopy (¹H and ¹³C) and mass spectrometry. Its structure was elucidated through single-crystal X-ray diffraction. Photophysical studies using UV-visible spectroscopy showed a remarkable selectivity and sensitivity of 4 for Sn(II). The binding constant was found to be 1.9 × 10³ M⁻¹ and exhibited a low limit of detection of 0.057 ppm. Job's plot confirmed the 1 : 1 stoichiometry, i.e., the binding between 4 and Sn(II). Furthermore, real sample analysis performed using the receptor yielded a favorable outcome. Furthermore, ADMET and Molinspiration studies were conducted to assess the pharmacokinetic properties of 4. 4 showed great antibacterial properties against E. coli. Molecular docking was also carried out against the 1HNJ receptor of E. coli, which proved the potential antibacterial efficiency of 4.