An electrochemical azidation of least hindered tertiary and benzylic C(sp3)–H bonds

Abstract

We herein report a Cu-electrocatalyzed strategy for selective azidation of tertiary and benzylic C(sp³)–H bonds, affording the corresponding azides in consistently high yields. Compared to existing methods, this protocol offers significant advantages in terms of safety, operational simplicity, and scalability. Moreover, it demonstrates broad applicability in the late-stage functionalization of complex natural products and drug-like molecules, highlighting its promising potential for synthetic and medicinal chemistry applications.