Comparative in vivo PET imaging of silica microparticles: shape-dependent blood circulation and short-term biodistribution

Abstract

Particles at the nanometric–micrometric interface hold promise by combining the drug-loading capacity of microparticles with the systemic benefits of nanoparticles. We assess the in vivo behaviour in mice via PET imaging of silica rods and spheres (∼1 μm), showing different biodistributions thus highlighting the potential for shape-dependent targeting.