Issue 4, 2025
From the journal:

Dalton Transactions

Biophysical interactions between self-sufficient cytochrome P450 from Tepidiphilus thermophilus and ilaprazole†

Jaejeong You, ORCID logo ‡a   Yunha Hwang, ORCID logo ‡a   Yeon-Ju Jeong, ORCID logo b   Soo-Jin Yeom,bc   Chul-Ho Yun, ORCID logo bc   Hyun Goo Kang*d  and  Seung Jae Lee ORCID logo *ae  

* Corresponding authors

a Department of Chemistry, Jeonbuk National University, Jeonju 54896, Republic of Korea
E-mail: slee026@jbnu.ac.kr

b School of Biological Sciences and Biotechnology, Graduate School, Chonnam National University, Gwangju 61186, Republic of Korea

c School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Republic of Korea

d Department of Neurology, Jeonbuk National University, Hospital, Jeonju 54896, Republic of Korea
E-mail: hgkang@jbnu.ac.kr

e Research Institute for the Molecular Biology and Genetics, Jeonbuk National University, Jeonju 54896, Republic of Korea

Abstract

Proton pump inhibitors (PPIs), metabolized by cytochrome P450 (P450) enzymes, are widely used to inhibit gastric acid secretion. This study investigated CYP116B46, a self-sufficient monooxygenase with a reductase domain, to elucidate its interaction with ilaprazole, a PPI. Binding assays and docking simulations indicate that CYP116B46 serves as a suitable model for studying PPI metabolism.

Graphical abstract: Biophysical interactions between self-sufficient cytochrome P450 from Tepidiphilus thermophilus and ilaprazole

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Article information

DOI
https://doi.org/10.1039/D4DT03320E
Article type
Communication
Submitted
28 Nov 2024
Accepted
03 Jan 2025
First published
06 Jan 2025

Dalton Trans., 2025,54, 1354-1359

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Biophysical interactions between self-sufficient cytochrome P450 from Tepidiphilus thermophilus and ilaprazole

J. You, Y. Hwang, Y. Jeong, S. Yeom, C. Yun, H. G. Kang and S. J. Lee, Dalton Trans., 2025, 54, 1354 DOI: 10.1039/D4DT03320E

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