Electroreductive nickel-catalyzed 1,1-diarylation and 1,2-diacylation of alkenes

Abstract

Herein, we present an electrochemical nickel-catalyzed strategy for the 1,1-diarylation and 1,2-diacylation of alkenes. By electrochemically generating Ni(0) species, aryl halides or aroyl chlorides efficiently couple with alkenes under mild conditions to afford the target products. The method exhibits excellent substrate generality and functional group tolerance, enabling late-stage modification of natural products and pharmaceutical molecules, providing an efficient approach for alkene difunctionalization.