N-Heterocyclic carbene-catalyzed asymmetric synthesis of bis-ferrocene derivatives bearing two stereogenic planes

Abstract

The synthesis of ferrocene derivatives with dual planar chirality remains a significant challenge in asymmetric catalysis. This study presents an enantio- and diastereoselective N-heterocyclic carbene-catalyzed strategy to construct such compounds via a double desymmetrization reaction. Synthetic applications highlighted the versatility of these planar–planar chiral products in asymmetric synthesis as catalysts.