Diversity-oriented transformation of methyl triazine via sulfur-mediated pathways: access to 2,4-disubstituted triazines functionalized with thioamides and amides

Abstract

Herein, we report a sulfur-mediated strategy involving C-demethylation and C(sp³)–H bond activation for synthesizing triazine derivatives functionalized with thioamide or amide groups. This work provides a novel method for the functional group transformation of methyltriazines in the presence of sulfur and demonstrates good substrate compatibility.